Bernhard Windham's Mercury Paper




 Bernie sent me this paper for free public distribution. He is a public employee who has been monitoring environmental mercury contamination and it's consequences for some years. He has developed a thorough and noteworthy compilation of the facts presented in scientific journals.

He himself came down with a bewildering illness that, much to his surprise, was diagnosed as mercury poisoning. Bernie suspects that his mercury amalgam dental fillings are the root source of his own mercury contamination.

Below is what Bernie has researched both as a public employee studying environmental mercury contamination, and a suspected victim of mercury amalgam dental fillings.

Bernie's information is organized as lists of facts followed by a list of cited scientific journal references.

- Jeff Clark


Bernard Windham,Editor
RR2, Box 385A
Tallahassee,Fl 32322
904-878-9024


Facts about Mercury and Dental Amalgam

(with Medical Study References)


1. Dental amalgam contains about 50 % mercury. The average filling has 1/2 gram of mercury.

2.Mercury is the most toxic of the toxic metals. Mercury is:
(a) cytotoxic(kills cells) (2,27,33) [106,147,148,150,160]
(b) neurotoxic(accumulates in the brain and damages brain cells) (27,34) [85,111,147,148,160,162]
(c) immunotoxic(damages and weakens the immune system) (27,34,35,42,43,44,45,46,47,48,60) [77,78,105,117,127,128,146,155,160]
(d) endocrine system-disrupting chemical(affects pituitary gland) [85,105,113,146,149]
(e) reproductive and developmental toxin (2,3,4,20,22,24,31,37,38,39,49,41,49)[105,146,149,160,204].
(f) causes cardiovascular damage and disease(47,201,202,205).

3. Mercury crosses the blood brain barrier and is selectively stored in the pituitary gland of the brain. [85,113,146,162] The pituitary gland controls the body's endocrine system and secretes hormones that control most bodily processes, including the immune system and reproductive systems[146].

4. Mercury's biochemical damage at the cellular level include DNA damage, alteration of protein structure, alteration of the transport of calcium, induction of free radical formation, inhibition of glutathione peroxidase enzyme, endothial cell damage, and immune system damage. Only a few micrograms of mercury severely disturb cellular function and inhibit nerve growth(181). 98% of mercury found in the brain is in the methyl mercury form, the most toxic form(220). Most mercury in saliva was also organic.

5. Hormonal secretions of the pituitary gland that control bodily processes are at extremely low levels and extremely low levels of mercury are required to adversely affect hormonal secretions of the pituitary gland. Hormonal secretions affected at levels much lower than acute toxicity effects normally tested for[105,146].

6. Because of the extreme toxicity of mercury, only 1/2 gram is required to contaminate a 10 acre lake to the extent that a health warning would be issued by the government to not eat the fish[151,160]. Over half the rivers and lakes in Florida have such health warnings[160].

7. Some Florida panthers that eat birds and animals that eat fish containing very low levels of mercury(about 1 part per million) have died from chronic mercury poisoning[160]. Since mercury is an estrogenic chemical and reproductive toxin, the majority of the rest cannot reproduce. The average male Florida panther has higher estrogen levels than females, due to the estrogenic properties of mercury[105,160]. Similar is true of some other animals at the top of the food chain like alligators.

8. In addition to having estrogenic effects, mercury has other documented hormonal effects including effects on the reproductive system resulting in lowered sperm counts, defective sperm cells, and lowered testosterone levels in males and lowered levels of brain neurotransmitters dopamine, serotonin, and noreprenephrine[105,107,140,141],

9. An average amalgam filling contains 1/2 gram of mercury, and the average adult had at least 5 grams of mercury in fillings(unless most has vaporized). Mercury in solid form is not stable and vaporizes continuously, so that within 10 years more than half has been transferred to the brain and body of the host(34,47)[182].

10. The level of mercury in people with amalgam fillings causes a body burden of mercury much higher than they could get from eating contaminated fish from Florida waters with government health warnings. (WHO,183)

11. Running shoes with 1/2 gram of mercury in the heels were banned by several states, because the amount of mercury was considered dangerous to public health and created a serious disposal problem. Mercury from dental offices and human waste from people with amalgam fillings has much higher levels and is a major source of mercury
in Florida waters.

* More detailed descriptions and references are contained in [105,160]. References in parentheses were compiled by the Australasian Society of Oral Medicine and Toxicology. References in brackets were compiled by Bernard Windham.

II. Systemic Mercury Intake Level from Amalgam Fillings

1. Mercury in solid form is not stable and evaporates continuously from amalgam fillings in the mouth, being transferred over a period of time to the host(211). Mercury vapor from amalgam is the single largest source of systemic mercury intake for persons with amalgam fillings. (16,17,19,57,) [78-82,94,111,126,129,130,138,161,183,211,216]. Amalgam also releases tin and copper which also have toxic effects, with organic tin being much more neurotoxic than mercury(222).

2. Mercury vapor is absorbed at a rate of 80% through the lungs into the arterial blood and is also absorbed my oral mucosa. (31,40) [77,79,84,94,96,117,133,211]

3. On average for a person having amalgam fillings, vapor from amalgam fillings amounts to about 80% of total systemic intake. [78-82,93,94,179,211]

4. Having dissimilar metals in the teeth(e.g.-gold and mercury) causes electrical currents and much higher mercury vapor levels and levels in tissues. (19,27,30) Average mercury levels in gum tissue near amalgam fillings are 250 ppm, but are often 1200 ppm near a gold cap on an amalgam filling(30,25,47)[186,194]. Concentrations of mercury in oral mucosa for a population of patients with 6 or more amalgam fillings taken during oral surgery were 20 times the level of controls[174]. The level of mercury and copper released from high copper amalgam is as much as 50 times that of low copper amalgams[191]. High levels of mercury vaporize and are picked up by the body and bloodstream during dental work(high-speed grinding) on amalgam fillings, which results in much higher levels in the heart, brain, liver, and kidneys(219).

5. The average level of mercury in the urine of a person with amalgam fillings(1.9 parts per million) is approximately twice that of the FDA and EPA Action Level for bans on eating fish and food due to high mercury level(1 ppm) and can be as much as 50 times the EPA Critical Level. [134, 154,etc.,160]
The U.S. Agency for toxic Substances and Disease Registry standard (MRL) for acute inhalation exposure to mercury vapor is 0.02 mcg Hg/m3 and the MrL for chronic inhalation exposure is 0.014 mcg Hg/m3. Common levels found in persons with amalgam fillings are over 100 times these MRLs(217,209). Thus persons with amalgam fillings have levels of intraoral mercury vapor higher than the level considered to have significant health risk.
6. There is only a weak correlation between blood or hair mercury levels and body burden or level in a target organ[157]. Feces has a significant mercury burden in people with amalgam fillings, having a higher correlation to systemic body burden than urine or blood, which tend to correlate with recent exposure level.(47) [79,80] As damage occurs to kidneys over time, mercury is less efficiently eliminated[157].

7. Mercury accumulates in the brain, liver, kidneys, heart,and oral mucosa(1,20,31) [77,79,84,85,94 ,111,149,211,219]

8. The number of amalgam surfaces has a statistically significant correlation to :
(a) blood plasma mercury level (17) [84,133,211]
(b) urine mercury level (16) [76,77,138]
(c) oral mucosa and saliva [77,79,94,117,199,211]
(d) feces mercury [79,94,117]
(e) pituitary gland (14,16,19,25) [85,113]
(f) brain occipital cortex (14,16,19,25) [85,111,149,211]

9. A person with amalgam fillings has daily systemic intake from mercury vapor of between 3 and 70 micrograms of mercury, with the average being at least 12 micrograms per day.[77,83,85,179,211]. Total intake is proportional to the number and extent of amalgam surfaces, but other factors such as chewing gum and drinking hot liquids influence the intake significantly.(28,31,56) [135- 139,193,211]. Vapor emissions range up to 200 mcg/M3 (47)[193] and are much higher after chewing. Approx. 39% of those having amalgam fillings tested in a large German study had ingested mercury levels exceeding the WHO mercury standard(199).

10. The blood and kidney mercury load of a person with amalgam fillings is often 5 times that of a similar person without.(16)[79,80,82,84,93,111,136,138 The average blood level for one large population was 24.8 nmol/l[176]. Normal blood levels are less than 20 ppb, but health effects have been observed in patients in the upper part of this range[196]. A Swedish study estimated the total amount mercury swallowed per day from intra-oral vapor was 10 micrograms per day[177]. Other studies have found similar amounts(211).

11.Teeth are living tissue and have massive communication with the rest of the body via blood, lymph, and nerves. Mercury vapor (and bacteria in teeth ) have paths to the rest of the body. (34,etc.) One German study of mercury loss from vapor in unstimulated saliva found the saliva of those with amalgams had 5 times as much mercury as for controls[179].

12. Mercury crosses the blood brain barrier and is stored preferentially in the pituitary gland, hypothalamus, and occipital cortex in direct proportion to the number and extent of amalgam surfaces.(1,13,19,20,25,34,55a) [85,111,113,149] Thus mercury has a greater effect on the functions of these brain areas.

13. Some mercury entering nasal passages is absorbed directly into the olfactory lobe and brain without coming from blood.(34,47,55a).

14. Mercury is transported along the axons of nerve fibers (33,34,47,50).

15. Mercury from amalgam is transported freely via the blood after entering the blood through the lungs (19,34,35).

16. Mercury has a long half life in the body and brain, and chronic low level intake results in a slow accumulation in body tissues. (20,26,34,47) [etc.]

17. Methyl mercury is more toxic to some body processes than elemental mercury. Mercury from amalgam is methylated by bacteria in the mouth and intestines(51,53,54) [81.185]. Methyl mercury is 1000 times more potent in causing genetic damage than any other known chemical(Ramel, in(47)).

18. The level of mercury in the brain tissue of the fetus, new born, and young children is directly proportional to the number of amalgam surfaces in the mother's mouth. (61,etc.) [112,113,114]

19. Mercury from amalgam in pregnant women crosses the placenta and appears in amniotic fluid and fetal blood, liver, and pituitary gland within 2 days of placement(18,31) [113,162]. Mercury is often stored in breast milk and the fetus at much higher levels than that in the mother's tissues (18,19,22,23,40,41,61) [112,114]. The highest level is in the pituitary gland of the fetus which affects development of the endocrine,immune, and reproductive systems.

20. There is a significant correlation between the number of amalgam fillings of the mother and the level of the fetus and older infants[112,113,114], and also with the level in mothers milk(18,19,61) [112,113]. Fertile women should not be exposed to vapor levels above 10 mcg/M3 (61)[195].


III. Medical Studies Finding Health Problems Related to Amalgam Fillings

1. Toxic/allergic reactions often result in lichen planus lesions in oral mucosa or gums and play a roll in pathogenesis of periodontal disease. Removal of amalgam fillings usually results in cure of such lesions. [82,86,87,90,94,101,133,145,192]

2. Numerous studies have found long term chronic low doses of mercury cause neurological, memory, behavior, and mood problems(34) [71,74,107,108,109, 115, 119,140,141,196]. Organic tin compounds formed from amalgam are even more neurotoxic than mercury(222).

3. Studies of groups of patients with amalgam fillings found significantly more neurological, memory, mood, and behavioral problems than the control groups. (34) [107,108,109,140,141,196]

4. Mercury binds to hemoglobin in the red blood cells thus reducing oxygen carrying capacity(1,16,17,21,26,35,47), and at 1 ppm can destroy the membrane of redblood cells(35,47,22,17) and damage blood vessels- reducing blood supply to the tissues(34). These effects often result in fatigue and reduced energy levels [115,119,140,141,202,212]. Mercury also accumulates in the heart and damages mycardial and heart valves(Turpayev, in (47)).

5. Mercury amalgam exposure adversely affects the immune system(27,34,48) [77,78,118,199]. One of several effects is to increase the average blood white cell count by 2000 to 10000 (47). The increased white count usually normalizes after amalgam removal. Mercury also blocks the immune function of magnesium and zinc [197].

6. Mercury from amalgam interferes with production of cytokines, disabling early control of viruses and leading to enhanced infection[131].

7. A group of patients with amalgam fillings and complaints of systematic symptoms including central nervous system problems and a group of controls were given MRI tests. 81% of the group with health complaints had pathological MRI results including signs of degeneration of the basal ganglia of the brain, but none in the controls. 60% of the symptom group tested positive for immune system reaction to mercury. The authors concluded that immune reactions have an important role in development of brain lesions ,and amalgam fillings induce immune reactions in many patients[118].

8. Among a group of patients testing positive as allergic to mercury, low level mercury exposure was found to cause adverse immune system response, including reduction of in vitro production of tumor necrosis factor TNF alfa and interleukin-1. [152]

9. Patch tests for hypersensitivity to mercury have found from 2% to 42% to test positive[87,154,178]. In a study of medical students, 12.8% tested positive as allergic to mercury, and those testing positive had significantly higher average number of amalgam fillings than those not testing positive(and higher levels of mercury in urine[132]. Other studies have found increasing allergy to mercury related to amount of exposure and time period of exposure[156,etc.]. If this is a good estimate of the percent of Americans allergic to mercury, this would be about 30 million people especially vulnerable to increased immune system reactions to amalgam fillings. However, patch tests do not measure the total population getting toxic reactions from mercury. The most sensitive reactions are immune reactions, DNA mutations, and systemic effects(47).

10. Low level mercury exposure including exposure to amalgam fillings has been found to be associated with increased auto immune diseases , including lupus,Chrons disease, lichen planus, endometriosis (1, 14, 17, 19, 21, 25,27,34,35,42,43,44,45,47,49,55,60) [77,78,215]. Silver, like mercury, is released from amalgam fillings and stored in the body and has been shown to cause immune reactions and autoimmunity in animal studies [77, 78, 129]

11. People with amalgam fillings have an increased number of intestinal microorganisms resistant to mercury and many standard antibiotics. (47,58)[116,117] Studies have found a significant correlation between mercury resistance and multiple antibiotic resistance[116,117,161].

12. Mercury from amalgam binds to the -SH (sulphydryl) groups, resulting in inactivation of sulfur and blocking of enzyme function, producing toxicity. Sulfur is essential in enzymes, hormones, nerve tissue, and red blood cells. These exist in almost every enzymatic process in the body. Mercury also blocks the metabolic action of manganese and the entry of calcium ions into cytoplasm. Mercury from amalgam thus has the potential to disturb all metabolic processes(25,33,47,60)[180,197}. Mercury is transported throughout the body in blood and can affect cells in the body and organs in different ways.

13. Several studies found adverse health effects at mercury vapor levels of 1 to 5 mcg/M3 (47).

14. Mercury accumulates in the kidneys with increasing levels over time. Mercury exposure has been shown to adversely affect kidney function in occupational and animal studies(59,203,211,etc.). The Government's toxic level for mercury in urine is 30 mcg/L [189], but low levels in urine often mean high mercury retention and chronic toxicity problems.

15. Amalgam fillings produce electrical currents which increase mercury vapor release and may have other harmful effects(19,27,28,29,35,47,56)[194]. These currents are measured in micro amps. The central nervous system operates on signals in the range of nano-amps, which is 1000 times less than a micro amp(28). Negatively charged fillings or crown appear to cause higher mercury vapor losses(47).

16. Mercury from amalgam fillings is transferred to the fetus of pregnant women and children who breast feed at levels often higher than those of the mother(18,19,31,61) [112,113,114,195].

17. Since mercury is documented from studies of humans and animals to be a reproductive and developmental toxin[105,146], mercury can reduce reproductive function and cause birth defects and developmental problems in children. (2,3,4,20,24,31,37,38,39,40,41,49) Clinical evidence indicates that amalgam fillings leads to hormone imbalances that can reduce fertility(199). Some researcher's advise pregnant women should not be exposed to mercury vapor levels above 10 mcg/M3 (61)[195].

18. Mercury causes breaks in DNA (41,42,)[197]. Low non-cytotoxic levels of mercury induce dose dependent binding of mercury to DNA and significantly increased cell mutations[142] and birth defects[197].

19. Mercury by its effect of weakening the immune system contributes to increased chronic diseases and cancer. Amalgam fillings have also been found to be positively associated with mouth cancer(206).

20. In addition to the endocrine system disrupting effects of high mercury accumulation in the pituitary gland, mercury causes a reduction in thyroid production and an accumulation in the thyroid of radiation. Mercury's adverse influence on thyrocytes can play a major role in thyroid cancer etiology[144].
Mercury has been found to affect hormone production at very low concentrations(199).

21. Allergies and hair-loss were found to be 2-3 times as high in a group with large number of amalgam fillings compared to controls(199). Higher levels of hormone disturbances, immune disturbances, recurrent fungal infections were also found in the amalgam group.

22. There has been no evidence found that there is any safe level of mercury in the body that does not kill cells and harm body processes(WHO,183, etc.). Mercury levels of 10ppm severely disturb cellular function, and growth of nerve fibers are affected at much lower levels[181]. This is especially so for the pituitary gland of the developing fetus which is the most sensitive to mercury(2-4,19-24,30,31,36,37,39-44).

22. The level of mercury released by amalgam fillings is often more than the levels documented in medical studies to produce adverse effects(see previous text).



IV. Health Effects from Dental Personnel Exposure to Mercury Vapor

1. Dentists and dental personnel who work with amalgam are chronically exposed to mercury vapor.(1,6-12,32,34,36) [72,122,123,124,171,172,173] Studies note that carpeting in dental offices should be avoided as it is a major repository of mercury[188]. Mercury levels in urine of dental personnel average about 2 times that of controls(123,124,171) and was 43 nmol/liter for a population
surveyed in Sweden(171), which is above the Swedish occupational exposure guideline.

2. Drilling old amalgam fillings with only a saliva extractor and no other precautions produces mercury vapor levels 2 to 15 times occupational threshold limit values(30 micrograms/cubic meter)[120,219].

3. The average dental office exposure affects the body mercury level approximately the same as having 19 amalgam fillings[123,124,173].

4. Body burden increases with time and older dentists have median mercury urine levels about 4 times those of controls, as well as higher brain and body burdens(13,34) [70-74,122]. Some older dentists have mercury levels in some parts of the brain as much as 80 times higher than normal levels(14,34).

5. Dentists and dental personnel experience significantly higher levels of neurological, memory, mood, and behavioral problems, which increase with years of exposure(13,34,49) [69-74,88,122,188].

6. Female dental technicians who work with amalgam have significantly reduced fertility and lowered probability of conception(3,24)[121], and their children have significantly lower average IQ compared to the general population(13). The level of mercury excreted in urine is significantly higher for female dental assistants than dentists(171,172,173).

7. Many homes of dentists have been found to have high levels of mercury contamination used by dentists bringing it home on shoes and clothes[187].
8. Some studies have found increased risk of lung, kidney, brain, and CNS system cancers among dental workers(14,34)[143].

8. Autopsies of former dental staff found levels of mercury in the pituitary gland averaged over 10 times that of controls(99), as well as higher levels in the occipital cortex and renal cortex and thyroid.

V. Results of Removal of Amalgam Fillings

1. For the week following amalgam removal, body mercury levels increase approx. 30 % (unless Chelation is also used), but within 2 weeks levels fall significantly.[82,89]

2. Removal of amalgam fillings resulted in a significant reduction in body burden and body waste product load of mercury[75,82,88,89,93,95,96,125,200].

3. Total reduction in mercury levels in blood and urine is often over 80% within a few months[82,89,93,96,200].

4. There are extensive documented cases where removal of amalgam fillings led to cure of serious health problems such as periodontal diseases, immune system problems,epilepsy, blood conditions, depression, mental confusion,infertility, lupus, arthritis, tachycardia, universal reactors, etc. or significant improvement in symptoms[75,86-91,95-103,125,148,165.167.168,170,180,182, 192,199,200,222].

5. Some studies of patients with major neurological or degenerative diseases such as Alzheimers ,ALS,MS,Parkinson's,etc. have found evidence amalgam fillings may play a major role in development of that condition(66,67) [92,97,98,100,102,145,148,158,159,163,166,169,170,175,183,184,207,213,218,221] Very high levels of mercury are found in brain memory areas such as the cerebral cortex and hippocampos of patients with diseases with memory related symptoms[158]. Studies have found mercury related mental effects to be indistinguishable from those of MS(207). Mercury at extremely low levels interfers with formation of tubulin producing neurofibrillary tangles in the brain similar to those observed in Alzheimers patients with high levels of mercury in the brain(207). Also mercury binds with cell membranes interfering with sodium and potassium enzyme functions, causing excess membrane permeability, especially in terms of the blood-brain barrier [159,207]. Less than 1ppm mercury in the blood stream can impair the blood- brain barrier. Mercury was also found to accumulate in the mitochondria and interfere with their vital functions, and to inhibit cytochrome C enzymes which affect energy supply to the brain. Persons with extra Apo-E4 gene copies are especially susceptible to this damage(207,221).
In many cases removal of amalgam fillings and treatment for metal toxicity led to "cure' or significant improvement in health[97,100,102,148,170,207,213,222]. There is some evidence that some forms of leukemia are abnormal response to antigenic stimulation by mercury or other such toxins and removal of amalgam has led to remission in some cases(47)[180].


VI. Scientists and Government Panels or Bodies That Have Found Amalgam Fillings to be Unsafe.

1. A World Health Organization Scientific Panel concluded that there is no safe level of mercury exposure(183,208). The Chairman of the panel, Lars Friberg stated that "dental amalgam is not safe for everyone to use(208).

2. In 1987 the Federal Dept. of Health in Germany issued an advisory warning against use of dental amalgam in pregnant women(61). A Swedish National Mercury Amalgam Review Panel found that "from a toxicological point of view, mercury is too toxic to use as a filling material"[164]. The U.S. EPA found that removed amalgam fillings are hazardous and must be disposed of as hazardous waste(214). A Canadian Government study for Health Canada concluded that any person with any number of amalgam fillings receives exposure beyond that recommended by the USPHS Standard(209). Many of those researching amalgam related health effects including several very prominent scientists have concluded that the health effects are widespread and serious so that mercury should not be used as a filling material (1,18,19,26,36,38,61) [88,94,99,100,113,115,125,126,148,153,164,170,183,208,209,210,222].

3. The use of mercury amalgams has been banned for children and women of child-bearing age or put on a schedule for phase out by 4 European countries. The use of amalgam is declining in Europe and Germany's largest producer of amalgam has ceased production, The director of the U.S. Federal program overseeing dental safety advises against using mercury amalgam for new fillings.

References

References 1-67 are from the Paper "Scientifically proven Facts About Mercury & Dental Amalgam" by the Australasian Society of Oral Medicine and Toxicology

Additional References: Based on Abstracts from Medline medical articles

(edited by Bernard Windham, Chemical Engineer)

(68)K.A.Ritchie et al,"Psychomotor testing of dentists with chronic low level mercury exposure", J Dent Res 74:420, IADR Abstract 160(1995).

(69)D Gonzalez-Ramirez et a; "Uninary mercury, porphyrins, and neurobehavioral changes of dental worker in Monterey, Mexico, J Pharmocol Exp Ther 272(1): 264-274,1995

(70) N.J. Heyer et al, "Behavioral Effects of Low Level Exposure to HgO Among Dentists", Neurotoxicol Teratol 17(2):161-168(1995).

(71)S.C.Foo et al, "Neurobehavioral effects in Occupational Chemical Exposure", Environmental Research, 60(2): 267-273, 1993.

(72)D.L.Smith,"Mental effects of mercury poisoning",South Med J 71:904-5,1978. (73)RT McNerney et al, "Mercury Contamination in the Dental Office: A Review", NYS Dental Journal, Nov 1979, p457-458.

(74) D.G. Mantyla et al, "Mercury toxicity in the dental office: a neglected problem", JADA, 92:1189-1194, 1976.

(75)Katsunuma et al, "Anaphylaxis improvement after removal of amalgam fillings", Annals of Allergy, 1990, 64(5):472-75.

{76)A. Schulte et al, "Mercury Concentrations in Children with and without Amalgam Restorations", J.Dent Res 73(4): 980 A-334.

(77)I.Skare, "Mass Balance and Systemic Uptake of Mercury Released from Dental Fillings", Water, Air, and Soil Pollutio, 80(1-4):59-67, 1995.

(78)G.Drasch et al," Silver Concentrations in Human Tissues: the Dependence on Dental Amalgam",J Trace Elements in Medicine and Biology,9(2):82-7,1995.

(79) L.Bjorkman et al, "Mercury in Saliva and Feces after Removal of Amalgam Fillings", J Dent Res 75: 38- IADR Abstract 165, 1996.

(80)M.Osterblad et al, "Antimicrobial and Mercury Resistance among Persons with and without Amalgam Fillings", Antimicrobial Agents and Chem, 39(11):2499,1995

(81) L.I.Liang et al, "Mercury reactions in the human mouth with dental amalgams" Water, Air, and Soil pollution, 80:103-107.

(82) J.Begerow et al,"Long-term mercury excretion in urine after removal of amalgam fillings", Int Arch Occup Health 66:209-212, 1994.

(83) I.et al, "Human Exposure to Hg and Ag Released from Dental Amalgam

Restorations", Archives of Environmental Health 49(5):384-394, 1994.

(84) J.E.Abraham et al, "The Effect of Dental Amalgam Restorations on Blood Mercury Levels", J Dent Res 63(1): 71-73, 1984

(85) J.A.Weiner et al,"The relationship between mercury concentration in human organs and predictor variables",138(1-3):101-115,1993; & "An estimation of the uptake of mercury from amalgam fillings", Sci Total Environ, v168,n3,1995.

(86)E.R.Smart et al, "Resolution of lichen planus following removal of amalgam restorations", Br Dent J 178(3): 108-112,1995.

(87)A. Skoglund, Scand J Dent Res 102(4): 216-222, 1994; and 99(4):320-9,1991.

(88) M.Godfrey et al, Confirmation of mercury retention and toxicity using DMPS", J Advance Med 7(1):19-30, 1994.

(89)M.Molin et al, "Kinetics of mercury in blood and urine after amalgam removal", J Dent Res 74:420, IADR Abstract 159, 1995.

(90) P.Koch et al, "Oral lichenoid lesions,mercury hypersensitity, ...",Contact Dermatitis, 33(5):323-328.

(91) B. Lindqvist et al, "Effects of removing amalgam fillings from patients affecting the immune system", Med Sci Res 24(5): 355-356, 1966.

(92) L. Tandon et al, "Elemental imbalance studies by INAA on ALS patients", J Radioanal Nuclear Chem 195(1):13-19,1995; .

(93) L.Barregard et al, "People with high mercury uptake from their own dental amalgam fillings", Occup Envir Med 52: 124-128, 1995.

(94) F.Berglund, Case reports spanning 150 years on the adverse effects of dental amalgam, Bio-Probe, Inc., Orlando, Fl, 1995; ISBN 0-9410011-14-3.

(95)H.J.Lichtenberg, "Elimination of symptoms by removal of dental amalgam from mercury poisoned patients", J Orthomol Med 8:145-148, 1993.

(96) R. Stromberg et al, "A case of unusually high mercury exposure from amalgam fillings", Tandlakartidningen 88(10): 570-572, 1996.

(97) O. Redhe et al, "Recovery from ALS after removal of dental amalgam fillings", Int J Risk & Safety in Med 4:229-236, 1994.

(98) A. Seidler et al, "Possible environmental factors for Parkinson's disease",Neurology 46(5):1275-1284, 1996; & F.O.Vroom et al, "Mercury vapor intoxication", Brain 95: 305-318, 1972.

(99) M.Nylander et al, Mercury accumulation in tissues drom dental staff and controls", Swedish Dental Journal, 13:235-243, 1989.

(100) M.E. Godfrey, "Chronic illness in association with dental amalgam",

J Adv Med 3:247-255, 1990; & M.Hanson et al, "The dental amalgam issue: a review", Experientia, 47:9-22,1991.

(101) E.Henriksson et al, "Healing of Lichenoid Reactions followin Removal of Amalgam", J Clinical Periodontol, V22,N4, p287-94,1995.

(102)R.L. Siblerud et al,"Evidence that mercury from silver fillings may be an etiological factor in multiple sclerosis", Sci Total Environ,v142,n3,p191 , 1994; & "Mental health, amalgam fillings, and MS", Psychol Rep, 70(3 Pt2), 992, 1139-51; & T.Engalls,Am J Forensic Med Pathol, 4(1):1983, Mar, 55-61.

(103) A.P.Tanchyk,"Amalgam Removal for Treatment of Arthritis", Gen Dent, v42,n4, July 1994, p354-

(104) G.Drasch et al, "Mercury burden of human fetal and infant tissues", Europeon J Pediatr, v153,n8, p607-10, 1994.

(105) B.Windham, "Health, Hormonal, and Reproductive Effects of Endocrine Disrupting Chemicals" (including mercury), Annotated Bibliography ,1996.

(106) G.R.Bruce,"Cytotoxicity of retrofil materials", J Endod, v19,n6,p288-92, 1993

(107) R.L.Siblerud et al, Psychometric evidence that mercury from dental fillings may be a factor in depression,anger,and anxiety", Psychol Rep,v74,n1,1994.

(108)M.Henningsson et al,"Defensive characteristics in individuals with amalgam illness", Acta Odont Scand 54(3): 176-181,1996.

(109) Y.X. Liang et al,"Psychological effects of low exposure to mercury vapor",Environ Res, 60(2): 320-327, 1993; & T.Kampe et al, "Personality traits of adolescents with intact and repaired dentitions",Acta Odont Scand,44:95-,1986

(110) N.Roeleveld et al, "Mental retardation and parental occupation",

Br J Ind Med 50(10):945-954, 1993.

(111) M.Nylander et al, "Mercury concentrations in the human brain and kidneys and exposure from amalgam fillings", Swed Dent J 11:179-187, 1987.

(112) A.Oaskarsson et al, "Exposure to toxic elements via breast milk", Analyst, 120(3): 765-770, 1995.

(113) M.J.Vimy et al, Maternal-fetal distribution of mercury released from amalgam fillings", Am J Physiol 258:R939-R945,1990.

(114) G.Drasch et al, Eur J Pediatr 153:607-610,1994.

(115) VDM Stejskal et al, "MELISA: tool for the study of metal allergy",

Toxic in Vitro, 8(5):991-1000, 1994.

(116) A.O.Summers et al, Antimicorbial Agents and Chemotherapy,37(4):825-834, 1993; & The Physiologist 33(4), A-116,1990; & M.Vimy et al, Silver dental fillings provoke an increase in mercury and antibiotic resistan bacteria in the mouth and intestines of primates", APUA Newsletter, Fall, 1991.

(117)C.Edlund et al, "Resistance of the Normal Human Microflora to mercury and antimicrobials", Clin Infect Dis 22(6):944-950, 1996.

(118) L.Tibbling et al, Immunolocial and brain MRI changes in patients with suspected metal intoxication", Int J Occup Med Toxicol (2):285-294,1995.

(119) L.Ronnback et al, "Chronic encephalopaties induce by low doses of mercury or lead", Br J Ind Med 49:233-240, 1992.

(120) L.Pohl, "The dentist's exposure to elemental mercury during clinical work", Acta Odontol Scand,v53,n1,p44-48,1995.

(121)A.S.Rowland et al,"The Effect of Occupational Exposure to mercury vapor on the fertility of female dental assistants",Occup Environ Med, v55,n1,1994

(122) K.A.Ritchie et al, "Psychomotor testing of dentists with chronic low level mercury exposure", J Dent Res 74:420 IADR Abstract 160 (1995).

(123) I. Skare et al, "Mercury exposure of different origins among dentists and dental nurses", Scand J Work Environ Health, 16:340-347, 1990.

(124) I.Akesson et al, "Status of mercury and selenium in dental personel", Arch Environ Health, 46(2): 102-109, 1991.

(125) G. Hall, "Perspectives of Amalgam and Other Dental Materials", European Acadamy Symposium Article, Ostzenhausen,Germany, April 29, 1994.

(126) F.L.Lorscheider et al, "Mercury exposure from silver tooth fillings: emerging evidence questions a paradigm", FASEB J 9:504-508,1995.


(127)P. Moszczynski et al, "The behavior of T-Cells in the blood of workers
exposed to mercury",Med Lav 85(3):239-241,1994;
& "Lymphocytes, T and NK cells in men exposed to mercury",Int J Occup Med Environ Health,8(1):1995.
(128) M.L.S.Queiroz et al, "Immunoglobulin Levels in Workers Exposed to Inorganic Mercury", Pharmacol Toxicol 74:72-75, 1994.

(129) P.Hultman et al,"Adverse immunological effects and immunity induced by dental amalgam" FASEB J 8:1183-1190, 1994.

(130) S. Enestrom et al, "Does amalgam affect the Immune System?" Int Arch Allergy Immunol 106:180-203,1995.

(131) S.Ellermann-Eriksen et al, "Effect of mercuric chloride on macrophage- mediated resistance mechinisms against infection", Toxicology, 93:269- 297,1994.

(132) K.Sato et al, "An epidemiological study of factors relating to mercury sensitization", Arerugi 44(2): 86-92, 1995.

(133) M.Molin et al, "Mercury in plasma in patients allegedly subject to oral galvanism", Scand J Dent Res 95:328-334, 1987.

(134) A.M.Aronsson et al, "Dental amalgam and mercury", Biol Metals 2:25- 30,1989.
(135) L.Bjorkman et el, "Factors influencing mercury evaporation rate from dental amalgam fillings", Scand J Dent Res, 100(6): 354-360, 1992.

(136) D. Gay et al, "Chewing releases mercury", Lancet, 8123:985-98, 1979.

(137) B.Fredin, "Studies on the Mercury Release from Dental Amalgam Fillings", Swed J Biol Med No.3, 1988, pp8-15.

(138) D. Zander et al, "Studies on Human Exposure to Mercuy Amalgam Fillings", Zbl Hyg 190: 325-334, 1990.

(139) G. Sallsten et al, "Long term use of nicotine chewing gum and mercury exposure from dental amalgam", J Dent Res 75(1):598,1996.

(140) R.L.Siblerud, "Health Effects After Dental Amalgam Removal", JOrthomolecular Med 5(2): 95-106.

(141)R.L.Siblerud et al, "Evidence that mercury from dental fillings may be an etiological factor in smoking",Toxicol Lett,v68,n3,1993,p307- & v69(3):305.

(142) M.E.Ariza et al, "Mutagenic effect of mercury", InVivo 8(4):559-63,1994.

(143) P.Boffetta et al, "Carciagenicity of mercury", Scand J Work Environ Health, 19(1):1-7,1993; & J Occup Med, 36(11):1260-64, 1994.

(144)V.Y Zaichick et al,"Trace Elements and thyroid cancer",Analyst, 120(3),1995.

(145) D.E. Swartzendruber, Med Hyptheses, 1993, v41,n1, p31-34.

(146) T.Colborn(Ed.),Chemically Induced Atlerations in Functional Development,Princeton Scientific Press,1992 & Developmental Effects of Endocrine- Disrupting Chemicals",Eniron Heath Perspectives, V 101, No.5, Oct 1993.

(147)J.M.Wood,"Mechinisms for the Neurotoxicity of Mercury", in Organotrans- itional Metal Chemistry, Plenum Publishing Corp, N.Y, N.Y, 1987.& R.P. sharma et al, "Metals and Neurotoxic Effects", J of Comp Pathology,Vol 91, 1981.

(148)H.R.Casdorph, Toxic Metal Syndrome, Avery Publishing Group, 1995.

(149) B.Choi et al, "Abnormal neuronal migration of human fetal brain", Journal of Neurophalogy, Vol 37, p719-733, 1978; & L.Verschaeve, "Genetic damage induced by mercury exposure", Envir Res,12:306-10,1976.

(150)U.S. Public Health Service, "Toxicological profile of Mercury", 1988.

& J.Leiskir,"Cytotoxity of Silver amalgam", Scand J of Dental Res, 1974. (151) Electric Power Research Institute, EPRI Technical Brief:"Mercury in the

Environment", 1993; & EPRI Journal, April 1990.

(152) Langworth et al, Effects of low exposure to inorganic mercury on the human immune system", Scand J Work Environ Health, 19(6): 405-413.1993.

(153) International Acadamy of oral Medicine and Toxicology, "A Scientific Response to the American Dental Association Special Report and Statement of Confidence in Dental Amalgam, IAOMT, POB 608531, Orlando,32860- 8531.

(154) E.Djerasci et al, Int Dent J 19:481-8,1969; & A.M.Robinson et al, Contact Dermatitis due to Amalgam fillings",Arch Dermatol Syphilol, 59:p116-8,1949; & R.R.White et al, J Amer Dent assoc, 92:124-7,1976; & K.Nordlind et al, "Patch test reactions to metal salts in patients with oral mucosal lesions associated with amalgal fillings", Contact Dermatitis, 1992, 27:3, 157-160.

(155) L.D.Koller, "Immunotoxicology of Heavy Metals", Int J of Immunopharm,

2:269-279,1980; & Amer J Vet Res, vol34,p1457-,1973.

(156) E.G.Miller et al, "Prevelence of Mercury Hypersensitivity among Dental Students", 64:Abstract 1472, p338,1985.

(157) L.J Goldwater, "Toxicology of Inorganic Mercury", Annals: NY Acad Sci,

65:498-503,1957; & J.B.Nielsen et al, "Evaluation of Mercury in Hair & Blood as Biomarkers for Methylmercury Exposure", Arch of Toxicology, 1994,65(5):317-321.

(158) Wenstrup et al, Trace element imbalances in the brains of Alzheimers patients",Brain Research, Vol 533,p125-131,1990; &

D.W. Eggleston et al, J Prosthet Dent, 1987,58(6),704-7;

and Journal of the American Medical Assoc., Sept 96.

(159) L.D. Koller, Immunotoxicity of heavy metals", Int J of Immunopharmacology, V2,p269,1980; & Amer j Vet Res, Vol 34,1457,1973.

(160)B.Windham, "Health Effects of Toxic Metals: An Annotated Bibliography",1995. (161) F.L.Lorscheider et al, "Inorganic mercury and the CNS; genetic linkage of mercury and antibiotic resistance,Toxicology,1995,97(1): 19-22.

(162) N.K.Mottet et al, "Health Risks from Increases in Methylmercury Exposure",vol63:133-140,1985.

(163) Ahlrot et al, Nutrition Research, 1985 Supplement, & Second Nordic Symposium on Trace Elements and Human Health, Odense, Denmark, Aug 1987.
(164) Swedish National Dept. of Health, Mercury Amalgam Review Panel, 1987.

(165) G.Anneroth et al, "Comprehensive Medical Examination of patients with alleged adverse effects from dental amalgams", Acta Odontal Scand, 1992,50(2):101-11.

(166) H.Basun et al, J Neural Transm Park Dis Dement Sect, "Metals in plasma and cerebrospinal fluid in normal aging and Alzheimer's disease",1991,3(4):231-58

(167)R.Brehler et al,"Mercury sensitization in amalgam fillings", Dtsch med Wochenschr,1993,118(13):451-6.

(168) J.Laine et al, "Resolution of oral lichenoid lesions after replacement of amalgam restorations", Br J Dermatol, 1992,126(1):10-15.

(169) C.H.Ngim et al, Neuroepidemiology,"Epidemiologic study on the association between body burden mercury level and idiopathic Parkinson's disease", 1989, 8(3):128-41.

(170) R.L.Siblerud, "A commparison of mental health of multiple schlerosis patients with silver dental fillings and those with fillings removed", Psychol Rep, 1992, 70(3),Pt2, 1139-51.

(171) A.Jokstad, "Mercury excretion and ocuupational exposure of dental personnel", Community Dent Oral Epidemio, 18(3):143-8,1990.

(172) B.Nilsson et al, "Urinary mercury excretion in dental personnel", Swed Dent J, 1986,10(6):221-32.

(173) D.Zanders et al, "Mercury exposure of male dentists, female dentists, and dental aides", Zentralbl Hyg Umweltmed, 1992,193(4):318-28.

(174) B.Willershausen et al, "Mercury in the mouth mucosa of patients with amalgam fillings", Dtsch Med Wochenschr, 1992, 117:46, 1743-7.

(175) L.Larkfors et al,"Methylmercury induced alterations in the nerve growth factor level in the developing brain", Brain Res Dev BrainRes,62(2),1991,287-

(176) A.Jokstad et al, "Dental amalgam and mercury", Pharmacol Toxicol, 70(4),
1992,308-13.

(177) S.Olsson et al, "Daily dose calculations from measurements of intra-oral mercury vapor", J Dent Res, 71(2):414-23,1992.

(178) K.Nordlind et al, "Patch test reactions to salts in patients with amalgam restorations", Contact Dermatitis, 27(3):157-60,1992.

(179) A.Lussi, "Mercury release from amalgam into saliva", Schweiz Monatsschr ahnmed, 103(6):722-6,1993.

(180) O.F.Pinto et al, J Intl Acad Prev Med, Vol 3, No.2, 1976.

(181) R.P.Sharmo et al,"Metals and neurotoxic effects", J Comp Pathol , 91:235,1981.

(182) J Pleva, J Orthomol Psych, Vol 12, No.3, 1983.

(183) World Health Organization(WHO),1991, Environmental Health criteria 118, Inorgtanic Mercury, p36, WHO, Geneva;
& W.Craelium, J Epidemiology and Community Health, 32:155-65,1978.

(184) T.H.Ingalls, J Forsenic Med and Path, Vol 4, No 1, 1953.

(185) U.Heintze, Scand J Dent Res, 1983, 1991:150-2.

(186) H Reden, Odont Revy, 25,1971,207-210.

(187) P.A.Gronla et al, JADA, 1970, 81:923-25.

(188)I.I. Ship et al, School of Dental Research, Univ of Penn., Mar 1983.

(189) WHO and U.S.CDC, Tocicology Division, Atlanta, Ga.

(190) T.B. Eyl, Mod Med, Vol 38, 1970.

(191) C.Brune et al, Scand J Dent Res, 1983, 19:66-71.

(192) L.J. Calsakis et al, "Alergy to Silver Amalgams",Oral Surg,46:371-5,1978

(193) D.D.Gay et al, 1979, Lancet, May 5, 1985 & C.W.Svare et al, J Dent Res, The effects of amalgams on mercury levels in expired air", 60, 1981, p1668-.

(194) T.Fusayama et al, J Dental Res, 1963, 42:1183-1197.

(195) Koos & Loongo,"Pregnacy ...", Pediatrics, Vol 64, No.5, Nov 1970.

(196) Gowdy & Demes, 1978, in (47).

(197) J.Taylor, A Complete Guide to Mercury Toxicity from Dental Fillings, Scripps Pullishing.

(198) E.S. West et al, Textbook of Biochemistry, MacMillan Co, 1957,p853.

(199) I.Gerhard et al, Tubingen Univ. Gynecological Clinic,Heidelberg,1996.

(200) S.Langworth et al, "A case of high mercury exposurte from dental amalgam", Eur J Oral Sci 104:320-321,1996.

(201) J.T. Solonen et al, "Intake of mercury from fish and the risk of myocardial infarction and cardiovasculr disease in eastern Finnish men", Circulation, 1995; 91(3):645-55.

(202) T.Kishimoto et al, "Methylmercury injury of Cultured Human Vascular Endothelial Cells", Journal of Trace Elements in Experimental Medicine, 6(4): 155-163, 1993.

(203) S. Eti et al, "Renal Effect of Mercury from amalgam fillings", Pharmacology & Toxicology, 1995, 76(1): 47-9.

(204) W.D. Kuntz et al, "Maternal and cord blood background mercury levels", American Journal of Obstetrics & Gynecoology, 1982; 143(4): 440-3.

(205) M.F. Ziff et al, A Persuasive New Look at Heart Disease As It Relates to Mercury, Bio-Probe, Inc., ISBN 0-941011-08-9.

(206) R. Ma et al, "Association between dental restorations and carcinoma of the tongue", European Journal of Cancer. Part B, Oral Oncology, 1995; 31B(4): 232-4.

(207) Boyd Haley, Univ. Of Kentucky, "The Toxic Effects fo Mercury on CNS Proteins: Similarity to Observations in Alzheimer's Disease", IAOMT Symposium paper, March 1997.

(208) L.T.Friberg, "status Quo and perspectives of amalgam and other dental materials", International symposium proceedings, G.Thieme Verlag Struttgart, 1995.

(209) Mark Richardson, Environmental Health Directorate,Health Canada,
Assessment of Mercury Exposure and Risks from Dental Amalgam, 1995 (peer-reviewed report); & Bio-Probe Newsletter, May 1996.

(210) Mats Berlin, "Is amalgam in dental fillings hazardous to health?", Lakartidningen, 1992; 89(37):2918-23.

(211) M.J.Vimy and F.L. Lorscheider, Faculty of Medicine, Univ. Of Calgary, July 1991. (Study findings) & J. Dent. Res. 1985, 64:1069-75; &
J. Trace Elem. Exper. Med., 1990,3, 111-123.

(212) Ziff, M.F., "Documented clinical side effects to dental amalgams", ADV. Dent. Res., 1992; 1(6):131-134.

(213) Dr. C. Kousmine, Multiple Scherosis is Curable, 1995.

(214) "Amalgam declared hazardous", Dentistry Today, February, 1989, p1.

(215) K.W. Sehnert, "Autoimmune Disorders", Advance, Jan 1995, p47-48.

(216) F.L. Lorscheider et al, Lancet, 1991, 337,p1103; & T.W. Clarkson et al, in Biological Monitoring of Toxic Metals, Plenum Press, N.Y., p247-260.

(217) Agency for Toxic Substances and Disease Registry, U.S. Public Health Service, "Toxicological Profile for Mercury"(ATSDR TP93/10), 1994.

(218) A. Seidler et al, "Possible environmental or occupational factors for Parkinson's Disease", Neurology, 1996; 46(5): 1275-84.

(219) D.E. Cutright et al, "Systemic mercury levels caused by inhaling mist during hig-speed amalgam grinding", J Oral Med 28(4):100-104,1973 ; &
A.Nimmo et al, "Inhalation during removal of amalgam restorations", J Prosthet Dent, 63(2):1990 Feb, 228-33.

(220) C Arch Environmental Health, 19,891-905, Dec 1969.

(221) R. Golden et al, Duke Univ., "Dementia and Alzheimer's" Disease", Minnesota Medicine, 78:p25-29, 1995.

(222) M. Daunderer, "Improvement of Nerve and Immunological Damages after
Amalgam Removal", Amer. J. Of Probiotic Dentistry and Medicine, Jan 1991.


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